Gerardo Gamba Selected Research

Pseudohypoaldosteronism

1/2022	Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
1/2018	C-terminally truncated, kidney-specific variants of the WNK4 kinase lack several sites that regulate its activity.
1/2016	Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases.
1/2016	With no lysine L-WNK1 isoforms are negative regulators of the K+-Cl- cotransporters.
5/2015	Revisiting the NaCl cotransporter regulation by with-no-lysine kinases.
5/2012	Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process.
3/2009	Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
10/2008	WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.
4/2008	A novel protein kinase signaling pathway essential for blood pressure regulation in humans.
1/2008	WNK kinases, renal ion transport and hypertension.

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Gerardo Gamba Research Topics

Disease

39	Hypertension (High Blood Pressure) 01/2022 - 01/2002
13	Pseudohypoaldosteronism 01/2022 - 01/2003
11	Acute Kidney Injury (Acute Renal Failure) 03/2022 - 07/2007
11	Ischemia 01/2021 - 07/2007
11	Hyperkalemia 01/2021 - 01/2003
6	Acidosis 01/2021 - 01/2003
6	Fibrosis (Cirrhosis) 01/2021 - 01/2003
5	Inflammation (Inflammations) 01/2021 - 11/2014
4	Chronic Renal Insufficiency 01/2022 - 01/2013
4	Bartter Syndrome (Syndrome, Bartter) 05/2009 - 09/2004
3	Hypotension (Low Blood Pressure) 05/2015 - 04/2004
3	Reperfusion Injury 02/2014 - 07/2007
2	Heart Failure 01/2021 - 11/2013
2	Obesity 01/2020 - 01/2018
2	Insulin Resistance 01/2020 - 01/2018
2	Hypercalciuria 01/2018 - 02/2005
2	Body Weight (Weight, Body) 01/2018 - 11/2015
2	Hypertrophy 01/2018 - 01/2017
2	Proteinuria 01/2017 - 01/2005
2	Alkalosis 11/2014 - 06/2014
2	Osteoporosis 04/2013 - 09/2007
2	Neoplasms (Cancer) 04/2013 - 01/2013
2	Hypovolemia 09/2012 - 03/2009
1	Endotoxemia 01/2020
1	Lupus Nephritis 01/2019
1	Segmental glomerulosclerosis 01/2019
1	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2019
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018
1	Weight Gain 01/2018
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2016
1	Schizophrenia (Dementia Praecox) 06/2016
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2016
1	Polyuria 01/2016
1	Hypokalemia 05/2015
1	Gitelman Syndrome 02/2015

Drug/Important Bio-Agent (IBA)

15	Phosphotransferases (Kinase)IBA 10/2018 - 02/2005
13	SaltsIBA 01/2022 - 04/2004
9	Lysine (L-Lysine)FDA Link 12/2020 - 01/2003
8	salicylhydroxamic acid (SHAM)IBA 01/2021 - 07/2007
8	Spironolactone (Aldactone)FDA LinkGeneric 01/2019 - 01/2003
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2005
7	Member 3 Solute Carrier Family 12IBA 01/2018 - 01/2003
7	Messenger RNA (mRNA)IBA 11/2016 - 01/2005
6	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 01/2019 - 07/2007
6	AldosteroneIBA 01/2018 - 10/2009
5	ThiazidesIBA 01/2022 - 09/2004
5	PotassiumIBA 01/2022 - 02/2005
5	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 06/2008 - 01/2003
4	thiazide receptorIBA 01/2022 - 04/2004
4	Protein Kinases (Protein Kinase)IBA 01/2020 - 02/2005
4	Angiotensin IIIBA 01/2018 - 03/2009
3	DiureticsIBA 01/2021 - 09/2004
3	ChloridesIBA 01/2016 - 06/2008
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2015 - 01/2011
3	CollagenIBA 01/2013 - 01/2003
3	Cyclosporine (Ciclosporin)FDA LinkGeneric 07/2010 - 07/2007
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2017
2	Cullin Proteins (Cullins)IBA 01/2021 - 11/2014
2	Ammonium Chloride (Sal Ammoniac)FDA Link 01/2021 - 11/2013
2	CytokinesIBA 10/2020 - 01/2013
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2018
2	Pharmaceutical PreparationsIBA 01/2018 - 09/2007
2	CationsIBA 06/2016 - 02/2006
2	ElectrolytesIBA 01/2016 - 02/2005
2	Biomarkers (Surrogate Marker)IBA 01/2015 - 01/2011
2	Fibronectins (Fibronectin)IBA 01/2013 - 01/2003
2	K Cl- CotransportersIBA 09/2008 - 01/2004
2	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 06/2008 - 05/2006
2	Member 1 Solute Carrier Family 12IBA 06/2008 - 05/2006
2	Antihypertensive Agents (Antihypertensives)IBA 01/2008 - 09/2007
2	CreatinineIBA 01/2007 - 01/2005
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2007 - 01/2003
1	Phenobarbital (Luminal)FDA Link 01/2022
1	Proline (L-Proline)FDA Link 01/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 10/2021
1	Prorenin ReceptorIBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2020
1	GenisteinIBA 01/2020
1	Endothelin B ReceptorIBA 01/2019
1	alpha 1-Antichymotrypsin (alpha 1 Antichymotrypsin)IBA 01/2019
1	Nitric Oxide Synthase Type III (Endothelial Nitric Oxide Synthase)IBA 01/2019
1	Alanine (L-Alanine)FDA Link 01/2018
1	Hormones (Hormone)IBA 01/2018
1	Calcium-Sensing ReceptorsIBA 01/2018
1	Epithelial Sodium ChannelsIBA 01/2018
1	GeraniinIBA 01/2018
1	Aminobutyrates (Aminobutyric Acid)IBA 06/2016
1	gamma-Aminobutyric Acid (GABA)IBA 06/2016
1	Member 2 Solute Carrier Family 12IBA 06/2016
1	Bumetanide (Bumex)FDA LinkGeneric 06/2016
1	ReninIBA 04/2016
1	AngiotensinsIBA 04/2016
1	Hypoxia-Inducible Factor 1IBA 02/2016
1	Transforming Growth Factors (Transforming Growth Factor)IBA 02/2016
1	Tacrolimus (Prograf)FDA LinkGeneric 11/2015
1	NucleotidesIBA 02/2015

Therapy/Procedure

1	Liver Transplantation 03/2022
1	Nephrectomy 01/2021
1	Therapeutics 10/2016
1	Transplantation 11/2015